Class time and location

SMTWTh – 10:30-11:30 (SCI-S Room 132)

Textbook, readings, and lecturing style:

Molecular Biology of the Gene. 6th edition, by Watson et al.

The lectures will be given using powerpoint slides (see below). It is YOUR RESPONSIBILITY to print the material, come to the lectures, and take notes. You will be tested on the material I give in class and the book.

Attendance:

I will not give points for attending my lectures. You are a RESPONSIBLE student and you want to learn. Missing lectures will significantly affect your performance and grade. I do not intend to give lectures during my office hours or photocopy my lecture notes for you!

Academic dishonesty:

DO NOT CHEAT. You are smart and you can get the grade you want. Academic dishonesty will not be tolerated.

Tests and grading:

You will be given FOUR independent tests each of which covers specific chapters. Each test is worth 30%. Your lowest test grade will be dropped and your final grade will be the sum of the three highest scores in addition to the final. The final is worth 40% and will cover the entire course material with greater emphasis on the material that you have not been tested on. The tests will be a combination of multiple-choice questions and short answer ones. 

Important dates:

Exam1:  Tuesday 25/6/2024 (Lectures 1-11), Bonus1 due

Exam2: Tuesday 9/7/2024 (Lectures 12-19), Bonus2 due

Exam3: Thursday 25/7/2024 (Lectures 20-29), Bonus3 due

Final Exam: Saturday 27/7/2024 (Lectures 2-31) – 11:00-1:00, Bonus4-5 due

Enrolled students:

1. A

Lecture 1: General Introduction (371_Lec1)

Lecture 2: Model organisms (371_Lec2)

Lecture 3: Laws of inheritance (371_Lec3)

Lecture 4: Mendel’s monohybrid experiments (371_Lec4)

Video: How Mendel’s pea plants helped us understand genetics? – Thanks Fatemah Sadeq

Lecture 5: Mendel’s dihybrid experiments (371_Lec5)

Lecture 6: The location and identity of the genetic material (371_Lec6)

Lecture 7: The identity of the genetic material (371_Lec7)

Lecture 8: The chemical composition of the genetic material (371_Lec8)

Video: DNA building blocks

Video: The structure of DNA – Thanks to Asmaa Alghanem

Lecture 9: DNA: The double helix structure (371_Lec9)

Video: The DNA double helix discovery

Video: Pauling triplet helix

Video: James Watson – Basepairing

Video: Chargaff’s rule

Video: The double strands

Lecture 10: Genome organization (371_Lec10)

Video: DNA packaging – Basic

Lecture 11: Genome organization: eukaryotes (371_Lec11)

Video: DNA packaging – Advanced

Lecture 12: DNA: Replication experiments (371_Lec12)

Video: DNA structure and replication

Lecture 13: DNA replication in prokaryotes: The elements of replication (371_Lec13)

Lecture 14: DNA replication in prokaryotes: The process of replication (371_Lec14)

Video: DNA replication – Thanks to Asmaa Alghanem

Video: DNA replication – Basic

Video: DNA replication – Advanced

Lecture 15: DNA replication in eukaryotes and phage (371_Lec15)

Video: Telomere replication – Thanks Nutaila Almahfudhi

Lecture 16: Transcription (371_Lec16)

Fun reads: 60 years ago, Francis Crick changed the logic of biology, Matthew Cobb

Lecture 17: Transcription in prokaryotes (371_Lec17)

Video: Transcription – Basic

Video: Transcription – Advanced

Lecture 18: Transcription in eukaryotes (371_Lec18)

Video: Eukaryotic mRNA splicing

Video: Eukaryotic mRNA Transcription – Thanks Rufaida Negm

Lecture 19: The genetic code (371_Lec19)

Video: The Triplet Code

Video: Ribosome binding assay – Thanks Haya Alshammari

Lecture 20: Amino acids and proteins (371_Lec20)

Video: Protein Structure and Folding – Thanks Althuraya Alaskar

Lecture 21: Translation: The tRNA and rRNA (371_Lec21)

Lecture 22: Translation in prokaryotes (371_Lec22)

Video: Translation – Basic

Video: Translation – Advanced

Lecture 23: Translation in eukaryotes (371_Lec23)

Video: Eukaryotic Translation – Thanks Fatima Baabbad

Lecture 24: Regulation of gene expression: I. Generalities (371_Lec24)

Lecture 25: Regulation of gene expression: II. Lambda (λ) phage repressor (371_Lec25)

Lecture 26: Regulation of gene expression: III. Prokaryotic regulation (371_Lec26)

Video: Lac Operon – Thanks Battol Samaro

Lecture 27: Regulation of gene expression: IV. Eukaryotes (part 1) (371_Lec27)

Lecture 28: Regulation of gene expression: IV. Eukaryotes (part 2) (371_Lec28)

Lecture 29: Regulation of gene expression: IV. Eukaryotes (part 3) (371_Lec29)

Lecture 30: Mutations (371_Lec30)

Lecture 31: Point mutations (371_Lec31)

Lecture 32: Chromosomal mutations (371_Lec32)

 Lecture 33: Sources of mutations ()

Lecture 34: DNA repair ()

Figures, photos, and graphs in my lectures are collected using google searches.  I do not claim to have personally produced the material (except for some). I do cite only articles or books used. I thank all owners of the visual aid that I use and apologize for not citing each individual item.  If anybody finds the inclusion of their material in my lectures a violation of their copy rights, please contact me via email (hhalhaddad@gmail.com).